Why Nervous System Dysregulation Might Be Worsening Your Autoimmune Disease
Discover the hidden triggers behind your autoimmune
flare-ups
UNDERSTANDING THE NERVOUS SYSTEM AND AUTOIMMUNE DISEASE
When we think about autoimmune diseases, we often focus on the immune system attacking the body’s healthy tissues. But behind the scenes, another system is hard at work, influencing these attacks—our nervous system. Particularly, dysregulation in the nervous system can exacerbate or even trigger autoimmune conditions, setting the stage for chronic inflammation and further immune dysfunction.
Autoimmune diseases like rheumatoid arthritis, Hashimoto’s thyroiditis, lupus, and others occur when the body mistakenly identifies its own tissues as foreign invaders. The immune system launches an attack, leading to inflammation, tissue damage, and a host of debilitating symptoms. But what if the missing link in the rise of autoimmune diseases lies not just in the immune system itself, but in a deeper, more systemic imbalance involving the nervous system?
HOW NERVOUS SYSTEM DYSREGULATION IMPACTS IMMUNE FUNCTION
The nervous system and the immune system are in constant communication. Through the release of neurotransmitters and hormones, the nervous system can either suppress or stimulate the immune system. In a balanced state, the nervous system helps regulate immune responses, ensuring they are appropriately aggressive when needed but able to retreat once the threat (like infection) is neutralized.
However, when the nervous system becomes dysregulated, it can lead to chronic activation of the immune system. This chronic stress response, mediated by the hypothalamic-pituitary-adrenal (HPA) axis, causes the release of stress hormones like cortisol and adrenaline. Over time, this persistent activation wears down the body’s regulatory mechanisms, contributing to systemic inflammation—a hallmark of autoimmune diseases.
In particular, when the vagus nerve—a critical component of the parasympathetic nervous system—becomes dysfunctional, the body’s ability to regulate inflammation is impaired.
ARTICLE CONTINUES BELOW
THE CONNECTION BETWEEN STRESS, THE HPA AXIS, AND AUTOIMMUNITY
Stress has long been recognized as a major contributor to autoimmune disease exacerbations. When the HPA axis is overstimulated by chronic stress, the body enters a prolonged state of “fight or flight,” leading to:
Increased cortisol levels: Cortisol, while anti-inflammatory in the short term, becomes detrimental when chronically elevated. Over time, it can suppress the immune system's ability to differentiate between self and non-self, contributing to autoimmune attacks.
Altered immune function: Chronic stress can increase the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which are commonly elevated in autoimmune diseases like lupus and rheumatoid arthritis.
Chronic stress can also alter the gut-brain axis, which has major implications for the development and management of autoimmune disease. This is where the gut microbiome and vagus nerve play a pivotal role.
GUT HEALTH AND AUTOIMMUNE DISEASE: THE MICROBIOME LINK
The gut plays a central role in immune system regulation—about 70% of the body’s immune cells are housed in the gut-associated lymphoid tissue (GALT). The GALT acts as a training ground for immune cells, helping the body learn to recognize harmful pathogens while tolerating the body’s own tissues. The gut microbiome, a complex ecosystem of trillions of microorganisms, including bacteria, fungi, and viruses, heavily influences this delicate balance.
The gut microbiome is not just a passive participant in digestion but an active player in regulating immune function. Studies show that the diversity and composition of the gut microbiota can significantly influence immune responses. For example, a diverse microbiome is generally associated with better health outcomes, while a loss of microbial diversity (as seen in dysbiosis) is linked to inflammatory and autoimmune conditions.
Research highlights that alterations in the gut microbiome can precede the onset of autoimmune diseases like multiple sclerosis (MS) and rheumatoid arthritis (RA). These changes are often characterized by a reduction in beneficial bacteria such as Bacteroides fragilis and an increase in inflammatory bacteria like Firmicutes.
HOW DYSBIOSIS TRIGGERS AUTOIMMUNE REACTIONS
Dysbiosis, or an imbalance between beneficial and harmful bacteria in the gut, has been implicated in the development and progression of autoimmune diseases. Normally, the gut lining serves as a protective barrier, preventing harmful substances from entering the bloodstream. However, when dysbiosis occurs, this barrier becomes compromised, leading to intestinal permeability, commonly known as "leaky gut."
Leaky gut allows harmful substances, such as lipopolysaccharides (LPS)—molecules found on the outer membrane of certain bacteria— to escape into the bloodstream. Once in the bloodstream, LPS triggers an immune response by activating toll-like receptors (TLRs) on immune cells. This sets off a cascade of pro-inflammatory cytokines, like tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which can lead to widespread inflammation.
Studies note that elevated levels of LPS in the bloodstream are strongly associated with chronic inflammatory diseases, including Crohn's disease, type 1 diabetes, and lupus. This chronic inflammation compromises immune tolerance, increasing the risk that the immune system will mistakenly attack the body’s own tissues, leading to the development or worsening of autoimmune conditions.
The Science Behind Leaky Gut and Autoimmune Disease
The concept of leaky gut is supported by research linking increased gut permeability to various autoimmune diseases. For example, studies have shown that patients with type 1 diabetes and celiac disease exhibit higher levels of gut permeability compared to healthy controls. Researchers suggest this allows antigens and microbial by-products to enter the bloodstream, triggering an autoimmune response.
Moreover, patients with rheumatoid arthritis (RA) have been found to have increased levels of LPS and pro-inflammatory cytokines in their bloodstream. This suggests that gut barrier dysfunction not only drives inflammation but may also play a pivotal role in exacerbating autoimmune attacks on joints and tissues.
THE ROLE OF THE GUT-BRAIN AXIS AND THE VAGUS NERVE IN AUTOIMMUNE DISEASE
The gut-brain axis is a bidirectional communication network that links the gut and brain through neural, hormonal, and immune pathways. This intricate relationship plays a key role in maintaining homeostasis within both systems. One of the most critical components of this network is the vagus nerve—a major communication pathway within the parasympathetic nervous system. The vagus nerve helps relay signals between the brain and gut, regulating not only digestion and mood but also immune responses.
When dysbiosis—an imbalance of gut bacteria—occurs, it disrupts this gut-brain communication, potentially leading to both immune dysfunction and nervous system dysregulation. This connection becomes especially significant in autoimmune diseases, where chronic gut inflammation can influence brain function and vice versa. For example, individuals with inflammatory bowel disease (IBD) are often at higher risk of developing anxiety and depression, a link that is primarily mediated by the gut-brain axis.
The Vagus Nerve's Role in Modulating Inflammation
The vagus nerve plays a protective role by regulating inflammation through the cholinergic anti-inflammatory pathway. When the vagus nerve is stimulated, it releases acetylcholine, a neurotransmitter that dampens the production of pro-inflammatory cytokines, preventing the immune system from overreacting. This is crucial in autoimmune diseases, where unchecked inflammation can worsen disease progression.
However, when vagal tone (a measure of vagus nerve activity) is low—often due to chronic stress, poor diet, or lack of sleep—the vagus nerve's ability to regulate inflammation is compromised. This results in chronic inflammation and an increased risk of autoimmune conditions. Research has shown that vagus nerve stimulations significantly reduce inflammation in patients with rheumatoid arthritis, offering potential therapeutic benefits for autoimmune diseases.
The Impact of Low Vagal Tone on Autoimmune Diseases
Low vagal tone is associated with several key health issues, especially within the context of autoimmune diseases:
Increased gut permeability (leaky gut): When vagal tone is low, gut motility and secretions are impaired, which compromises the gut barrier and leads to a "leaky gut." This allows toxins and undigested food particles to cross the intestinal barrier, triggering autoimmune flares as the immune system responds to these invaders.
Chronic inflammation: Without proper modulation from the vagus nerve, the body struggles to shut off inflammation, exacerbating the progression of autoimmune diseases such as Crohn’s disease, multiple sclerosis (MS), and rheumatoid arthritis.
Mental health and immune dysregulation: There is a well-established link between mental health disorders such as depression and anxiety and autoimmune diseases. Low vagal tone is often seen in patients who suffer from
HOW TO IMPROVE VAGAL TONE, GUT HEALTH, AND IMMUNE FUNCTION
Restoring balance to the nervous system, particularly the vagus nerve, and supporting gut health are critical strategies in managing autoimmune disease.
Breathwork and Meditation | A Path to Nervous System Restoration
Breathwork and meditation are powerful tools that can help restore balance to the nervous system by stimulating the vagus nerve, which is crucial in regulating inflammation. Engaging in slow, deep diaphragmatic breathing activates the parasympathetic nervous system, moving the body out of "fight or flight" and into "rest and digest" mode. This shift reduces stress levels, calms the immune response, and diminishes inflammation—all critical factors in managing autoimmune diseases.
Scientific Support for Breathwork and Vagal Activation | Research indicates that diaphragmatic breathing can significantly improve vagal tone, which directly influences the body’s ability to manage stress and inflammation. Studies have shown that practicing 10 minutes of diaphragmatic breathing can increase heart rate variability (HRV)—a key marker of vagal activity associated with better immune regulation and lower systemic inflammation.
In addition, mindfulness-based stress reduction (MBSR), which incorporates meditation, has been scientifically shown to lower levels of pro-inflammatory cytokines like interleukin-6 (IL-6)—a biomarker commonly elevated in autoimmune conditions. Studies have found that participants who practiced MBSR had significantly lower IL-6 levels after just eight weeks.
#CellCare Ritual: Breathwork & Meditation for Autoimmune Health
To help stimulate the vagus nerve and reduce inflammation, incorporate this daily #CellCare Ritual:
Morning Breath Activation (5-10 minutes):
Find a quiet space, sit comfortably, and place one hand on your belly.
Slowly inhale through your nose, expanding your abdomen.
Exhale gently through your mouth, feeling your belly fall.
Repeat 10 times, focusing on your breath to start the day calm and centered.
Mindful Midday Check-In (2-3 minutes):
During the day, take short mindful breaks to practice deep breathing, especially during moments of stress. Just a few minutes of this can shift your nervous system back into balance.
Evening Meditation (5 minutes):
Before bed, engage in 5 minutes of guided meditation or breathwork to promote relaxation, reduce anxiety, and enhance sleep quality, further activating your parasympathetic system.
By making breathwork and meditation a regular part of your daily routine, you support the vagal tone needed to reduce inflammation, improve immune function, and manage the symptoms of autoimmune disease. This simple yet effective practice can help restore balance to both your nervous and immune systems over time.
Probiotics and Prebiotics | Nourishing the Gut for Immune Balance
Probiotics and prebiotics are essential for supporting gut health, which is directly linked to regulating the immune system. Probiotic-rich foods introduce beneficial bacteria into the gut, helping restore a balanced microbiome. Prebiotics, on the other hand, are dietary fibers that nourish and feed these beneficial bacteria, supporting their growth and activity. Together, they help maintain a healthy gut barrier, reduce inflammation, and improve gut permeability—key factors in managing autoimmune conditions.
The Science Behind Probiotics and Prebiotics | The gut microbiome plays a central role in immune system function, with 70% of the immune system residing in the gut. Dysbiosis, or microbial imbalance, is often found in patients with autoimmune diseases such as Crohn's disease, rheumatoid arthritis, and type 1 diabetes. Studies have shown that probiotic supplementation can restore microbial diversity and reduce systemic inflammation. In one study, individuals with rheumatoid arthritis who consumed probiotic-rich foods experienced a significant reduction in pro-inflammatory markers like C-reactive protein (CRP).
Similarly, prebiotics, such as inulin and fructooligosaccharides (FOS), have been shown to enhance gut health by increasing the population of beneficial bacteria like Bifidobacteria and Lactobacillus. Research highlights that prebiotics can reduce intestinal permeability, commonly known as "leaky gut," which is a key driver of inflammation in autoimmune diseases.
#CellCare Ritual | Probiotic and Prebiotic Support for Gut Health
Incorporating both probiotics and prebiotics into your daily routine can help restore gut balance and support immune function. Try this CellCare Ritual:
Morning Prebiotic Boost: Start your day with a prebiotic-rich smoothie or breakfast. Include foods like bananas, asparagus, or a tablespoon of inulin powder to nourish beneficial bacteria.
Midday Probiotic Snack: Enjoy a serving of probiotic-rich foods such as kefir, kimchi, or sauerkraut with lunch. These fermented foods introduce helpful bacteria into your gut, improving microbial diversity.
Evening Gut Health Support: Incorporate another dose of probiotics in the evening, such as a small serving of yogurt or a probiotic supplement, to continue supporting gut health and digestion overnight.
Integrating these nutrient-dense foods into your diet regularly promotes a balanced microbiome, reduces inflammation, and strengthens your gut barrier. This, in turn, helps regulate immune responses and reduces the likelihood of autoimmune flare-ups. Probiotic and prebiotic support is a simple yet effective way to improve gut health and manage autoimmune disease over time.
Polyphenol-Rich Foods | Fighting Inflammation and Supporting Vagal Nerve Health
Polyphenols are powerful plant compounds found in foods like berries, green tea, and olive oil, and they play a crucial role in reducing inflammation and supporting gut and nervous system health. These antioxidants help combat oxidative stress and inflammation in the gut, while also supporting the vagus nerve’s function in regulating the immune system. Incorporating polyphenol-rich foods into your diet can reduce gut inflammation, promote a balanced microbiome, and improve vagal tone, all of which are essential in managing autoimmune conditions.
The Science Behind Polyphenols and Gut Health | Polyphenols have been extensively studied for their anti-inflammatory and antioxidant properties. A study published in The American Journal of Clinical Nutrition found that polyphenol-rich foods like berries and green tea can modulate the gut microbiome, promoting the growth of beneficial bacteria like Bifidobacteria and Lactobacillus, while reducing harmful bacteria. This shift in the gut environment helps reduce intestinal permeability and inflammation, both of which are critical in preventing autoimmune flares.
Furthermore, polyphenols can enhance vagal nerve activity. The vagus nerve regulates inflammation via the cholinergic anti-inflammatory pathway, and polyphenols have been shown to increase acetylcholine production, helping the vagus nerve reduce inflammation more effectively. Studies suggest that olive oil, rich in polyphenols, can improve vagal tone and help reduce systemic inflammation, a key factor in autoimmune diseases like rheumatoid arthritis and lupus.
#CellCare Ritual | Polyphenol Power for Gut and Nerve Health
Incorporating polyphenol-rich foods into your daily routine can help reduce inflammation and support gut health and vagal nerve function. Follow this simple #CellCare Ritual to harness the power of polyphenols:
Morning Antioxidant Boost: Start your day with a polyphenol-rich smoothie or breakfast. Include berries like blueberries, strawberries, or raspberries, which are high in antioxidants, and consider adding a cup of green tea to further support gut health.
Midday Mediterranean Lunch: Incorporate extra virgin olive oil into your lunch by using it in salads or as a dressing. Olive oil is rich in polyphenols that can help reduce inflammation and improve vagal tone. (remember, more is not always better; a little bit goes a long way)
Evening Polyphenol-Infused Relaxation: Enjoy a cup of herbal tea rich in polyphenols, such as green tea or chamomile, to wind down at the end of the day while supporting your vagus nerve and gut health.
Consisting polyphenol-rich foods to your diet can reduce gut inflammation, support vagal nerve function, and promote a healthier immune system. These potent compounds offer a natural way to enhance gut health and manage the symptoms of autoimmune disease over time.
Intermittent Fasting | A Reset for Your Gut and Nervous System
Intermittent fasting (IF) is an eating pattern that alternates between periods of eating and fasting. Emerging research suggests that IF can help reduce systemic inflammation, promote immune regulation, and give both the gut and nervous system time to reset and recover. This approach has gained attention as a potential tool in managing autoimmune conditions, as it allows the body to enter a period of rest, during which cellular repair and immune modulation can occur more effectively.
The Science Behind Intermittent Fasting and Immune Regulation | Intermittent fasting has been shown to positively influence immune function by reducing pro-inflammatory markers and enhancing autophagy—a process where the body clears out damaged cells and regenerates new ones. This is particularly important in autoimmune diseases, where inflammation often goes unchecked. Studies have found that intermittent fasting can reduce levels of pro-inflammatory cytokines such as TNF-α and IL-6, both of which are elevated in autoimmune conditions.
Additionally, intermittent fasting has been shown to improve gut health by allowing the digestive system time to rest and repair. This process helps strengthen the intestinal barrier, reducing gut permeability (leaky gut), a common trigger for autoimmune flare-ups. IF has also been linked to enhanced vagal nerve function, as periods of fasting can increase heart rate variability (HRV), a key indicator of vagal tone.
#CellCare Ritual | Intermittent Fasting for Gut and Immune Health
If you are new to intermittent fasting, adopting a gradual approach that suits your lifestyle and health needs is essential. Follow this CellCare Ritual to integrate intermittent fasting into your routine:
Start with a 12:12 Fast: Begin by fasting for 12 hours overnight, with a 12-hour eating window. For example, finish dinner by 7 PM and have your next meal at 7 AM. This allows your body time to rest and engage in cellular repair overnight.
Progress to 16:8 Fasting: As you become more comfortable with fasting, you can extend the fasting window to 16 hours, with an 8-hour eating period. During this time, consume nutrient-dense, anti-inflammatory foods like vegetables, lean proteins, and healthy fats.
Stay Hydrated and Nourished During Fasting: Drink plenty of water, herbal teas, or even bone broth during your fasting window to stay hydrated and support gut health. Avoid sugary drinks or snacks that might break the fast and stimulate an inflammatory response.
Mindful Eating During the Eating Window: To further enhance gut and immune health, focus on incorporating whole foods rich in polyphenols, probiotics, and prebiotics during your eating periods.
Incorporating intermittent fasting into your routine allows the body to reset, reduce inflammation, and regulate immune responses. This can help manage the symptoms of autoimmune diseases by improving gut health and supporting nervous system regulation. Over time, IF can become a powerful tool for enhancing overall wellbeing and promoting a balanced immune system.
Yoga and Physical Activity | Stimulating the Vagus Nerve and Reducing Inflammation
Yoga and physical activity are essential practices for improving overall health, but their specific benefits in managing autoimmune diseases are particularly profound. Yoga, especially when combined with diaphragmatic breathing, directly stimulates the vagus nerve, helping to regulate the nervous system and reduce systemic inflammation. Regular physical activity, in general, boosts immune function, lowers inflammation, and supports mental health—all crucial factors in managing autoimmune conditions.
The Science Behind Yoga, Physical Activity, and Vagal Stimulation | Yoga has been shown to increase vagal tone, which improves the body’s ability to respond to stress and regulate immune function. Studies have found that yoga practitioners had higher HRV (heart rate variability), a key marker of vagus nerve health, compared to non-practitioners. Higher HRV is associated with reduced inflammation and a more balanced immune response, both of which are essential for those with autoimmune diseases. (FYI: yoga is not about touching your toes).
Yoga practices, particularly those that focus on deep breathing and restorative poses, promote a calm nervous system and reduce the levels of pro-inflammatory cytokines such as TNF-α and IL-6. In addition, regular physical exercise, including aerobic and strength training, helps reduce chronic inflammation by increasing the production of anti-inflammatory cytokines and improving muscle metabolism.
#CellCare Ritual | Yoga and Movement for Autoimmune Support
Incorporating both yoga and physical activity into your routine can be a powerful strategy for reducing inflammation and improving nervous system function. Try this #CellCare Ritual:
Morning Yoga Flow (10-15 minutes): Begin your day with a gentle yoga flow focused on poses that stimulate the vagus nerve. Incorporate poses like Child’s Pose (Balasana), Bridge Pose (Setu Bandhasana), and Cat-Cow (Marjaryasana-Bitilasana) while practicing slow, deep diaphragmatic breathing. These poses help activate the parasympathetic nervous system and reduce inflammation.
Daily Movement Breaks: Integrate regular movement throughout the day to maintain circulation and reduce stiffness. Even short walks, stretching, or low-impact exercises can help stimulate the vagus nerve and improve muscle metabolism, reducing inflammation over time.
Strength and Aerobic Training (3-4 times a week): Aim for at least 150 minutes of moderate-intensity aerobic and strength training each week. Activities like brisk walking, cycling, or resistance exercises help reduce inflammation and improve cardiovascular health and mental wellbeing, both of which are linked to better autoimmune management.
Evening Restorative Yoga (5-10 minutes): Close your day with restorative yoga or gentle stretching to unwind and further support nervous system balance. Focus on poses like Legs Up the Wall (Viparita Karani) and Reclining Bound Angle Pose (Supta Baddha Konasana), paired with deep breathing to relax the body and prepare for restful sleep.
Incorporating yoga and physical activity into your daily life can support your vagus nerve, reduce inflammation, and improve immune function. Regular movement, whether it’s through yoga, walking, or strength training, is critical for managing autoimmune conditions and promoting long-term health.
Adequate Sleep | Restoring Inflammation and Supporting Vagal Nerve Function
Quality sleep is essential for both immune regulation and nervous system balance, particularly for individuals managing autoimmune diseases. Poor sleep is linked to increased systemic inflammation and impaired vagal tone, which can exacerbate the symptoms of autoimmune conditions. Aiming for 7-9 hours of restful, uninterrupted sleep each night is crucial for supporting immune health, reducing inflammation, and maintaining optimal nervous system function.
The Science Behind Sleep, Inflammation, and Vagal Tone | Lack of sleep has been shown to raise levels of pro-inflammatory cytokines, such as C-reactive protein (CRP) and interleukin-6 (IL-6)—both of which are commonly elevated in autoimmune conditions. The research found that individuals who experienced chronic sleep deprivation had significantly higher levels of inflammation and poorer immune function compared to those who regularly achieved sufficient rest.
In addition, sleep is vital for maintaining vagal nerve health. Studies indicate that adequate sleep improves heart rate variability (HRV), a key marker of vagal tone. Higher HRV is associated with better stress resilience and reduced inflammation. Conversely, poor sleep weakens vagal activity, making it more difficult for the body to regulate immune responses and inflammation, thus increasing the risk of autoimmune flares.
#CellCare Ritual | Sleep Optimization for Immune and Nervous System Health
To ensure quality sleep and support vagal function, integrate these steps into your #CellCare Ritual:
Consistent Sleep Schedule: Establish a regular sleep routine by going to bed and waking up at the same time each day, even on weekends. This consistency helps regulate your circadian rhythm, improving sleep quality and immune function.
Pre-Bedtime Wind Down: Before bed, engage in a relaxation ritual, such as reading, meditation, or gentle stretching. Avoid stimulating activities like screen time or heavy meals at least one hour before bedtime, as these can interfere with the body’s ability to wind down.
Optimize Your Sleep Environment: Make your bedroom a sanctuary for sleep by ensuring a cool, dark, and quiet environment. Use blackout curtains, white noise machines, or an eye mask to create a restful atmosphere.
Incorporate Vagal-Stimulating Practices: Before bed, practice deep breathing or meditation for 5-10 minutes to stimulate the vagus nerve and activate the parasympathetic nervous system. This will promote relaxation and prepare your body for restful sleep.
Support Sleep With Herbal Teas or Supplements: Herbal teas such as chamomile or valerian root can promote relaxation and help ease you into a peaceful night’s sleep. Additionally, supplements like magnesium may support better sleep by calming the nervous system.
Prioritizing 7-9 hours of quality sleep each night allows your body the necessary time to repair, regulate immune function, and support vagal nerve health. Quality sleep is one of the most impactful lifestyle factors in managing autoimmune disease, as it directly influences both inflammation and the nervous system’s ability to maintain balance.
Reducing Environmental Toxins: Protecting Gut Health and Immune Balance
Environmental toxins are pervasive in modern life and can have a detrimental effect on gut health, immune function, and nervous system regulation—especially for individuals with autoimmune diseases. Toxins from processed foods, household products, and environmental pollutants can exacerbate gut permeability (leaky gut) and trigger immune responses, leading to chronic inflammation. Reducing exposure to these toxins through a whole-foods-based diet, cleaner lifestyle habits, and mindful product choices is critical for managing autoimmune conditions and supporting both the gut and vagus nerve.
Specific Toxins and Their Impact on Autoimmune Health
Processed Food Additives: Artificial sweeteners (like aspartame and sucralose) and preservatives (such as BHT and BHA) can disrupt the gut microbiome and increase gut permeability. Research has found that common additives like emulsifiers damage the intestinal lining and contribute to chronic low-grade inflammation, a key driver of autoimmune diseases.
Pesticides and Herbicides: Chemicals like glyphosate, commonly used in non-organic farming, have been shown to disrupt the gut microbiota and increase the risk of autoimmune conditions by promoting gut dysbiosis and permeability. Studies have linked glyphosate exposure to alterations in the gut bacteria, increasing the likelihood of inflammatory responses.
Heavy Metals: Exposure to heavy metals like lead, mercury, and cadmium, often found in contaminated water and certain seafood, can impair the immune system and promote systemic inflammation. These metals accumulate in the body over time, leading to oxidative stress and exacerbating autoimmune conditions. Research suggests that chronic mercury exposure disrupts immune tolerance, increasing the risk of autoimmune diseases like lupus.
Phthalates and BPA: Phthalates and bisphenol A (BPA), found in plastic containers, food packaging, and personal care products, are endocrine-disrupting chemicals that interfere with hormone regulation and immune function. Studies have found that BPA exposure is linked to an increased risk of autoimmune thyroid disorders.
Airborne Pollutants: Air pollution, particularly fine particulate matter (PM2.5) and volatile organic compounds (VOCs), can trigger inflammatory responses in the body. Studies have shown that exposure to high levels of airborne pollutants increases the risk of autoimmune diseases by promoting oxidative stress and inflammation.
#CellCare Ritual: Reducing Toxin Exposure for Autoimmune Health
Making simple yet effective lifestyle changes can significantly reduce your exposure to harmful toxins. Try this CellCare Ritual to support gut health, immune function, and overall wellbeing:
Switch to Whole, Organic Foods: To minimize exposure to pesticides, additives, and preservatives, focus on a diet rich in whole, organic foods. Prioritize fruits, vegetables, and whole grains free from chemicals like glyphosate. Consider purchasing organic high-pesticide foods, such as those on the Environmental Working Group’s (EWG) Dirty Dozen list.
Use Non-Toxic Household Products: Replace conventional cleaning and personal care products with non-toxic alternatives free from phthalates, BPA, and harsh chemicals. Opt for natural cleaners, glass containers, and BPA-free products to reduce your exposure to toxins.
Filter Water and Limit Heavy Metal Exposure: Invest in a high-quality water filter to reduce exposure to heavy metals like lead and mercury. Avoid consuming fish known to be high in mercury, such as swordfish and king mackerel, and choose safer seafood options like wild-caught salmon or sardines. Better yet, don’t eat seafood because it’s not just about the mercury; it’s also about the microplastics.
Improve Indoor Air Quality: Use air purifiers, keep windows open for ventilation, and avoid synthetic air fresheners that release volatile organic compounds (VOCs). Reducing indoor pollutants will help lower inflammation and support respiratory and immune health.
Practice Regular Detoxification: Stay well-hydrated, eat fiber-rich foods, and incorporate sweating practices such as saunas or exercise to support the body’s natural detoxification processes. These habits help remove toxins stored in the body, reducing the inflammatory burden on the immune system.
Reducing exposure to these common toxins can significantly decrease gut permeability, lower systemic inflammation, and support a more balanced immune response. These lifestyle changes are essential for protecting both your gut and nervous system, helping you manage autoimmune conditions more effectively.
Crafting Your Healing Blueprint in the Lifestyle Design Lab
Effectively managing autoimmune diseases requires a comprehensive, integrative approach that goes beyond simply addressing symptoms. In the Lifestyle Design Lab, we focus on the intricate connections between the nervous system, gut health, and immune function, offering a space to craft your personalized healing blueprint.
Improving vagal tone through techniques such as breathwork, meditation, yoga, and sleep optimization helps calm the nervous system and reduce chronic inflammation. Likewise, supporting a balanced microbiome with probiotics, prebiotics, polyphenol-rich foods, and intermittent fasting enhances gut health and immune regulation, reducing the frequency of autoimmune flares.
Additionally, minimizing exposure to environmental toxins through intentional lifestyle choices fortifies both the gut and nervous system, allowing your body to heal more effectively. In the Lifestyle Design Lab, we provide the tools and community support needed to implement these strategies and design a lifestyle that empowers you to regain control over your health.
Taking small, consistent steps to support your body’s natural healing mechanisms can reduce autoimmune flares, enhance resilience, and cultivate lasting wellness, balance, and vitality.
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References:
Fasano, Alessio. "Leaky Gut and Autoimmune Diseases." Clinical Reviews in Allergy & Immunology 42, no. 1 (2012): 71-78.
Mayer, Emeran A. "Gut Feelings: The Emerging Biology of Gut–Brain Communication." Nature Reviews Neuroscience12, no. 8 (2011): 453-466.
Bonaz, Bruno, Véronique Sinniger, and Sylvie Pellissier. "The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract." Frontiers in Immunology 8 (2017): 1452.
Rogers, Geraint B., Damian J. Keating, Richard L. Young, Michael L. Wong, and Julio Licinio. "From Gut Dysbiosis to Altered Brain Function and Mental Illness: Mechanisms and Pathways." Molecular Psychiatry 21, no. 6 (2016): 738-748.
Maes, Michael, Marta Kubera, and Johannes C. Leunis. "The Gut-Brain Barrier in Major Depression: Intestinal Mucosal Dysfunction with an Increased Translocation of LPS from Gram-Negative Enterobacteria (Leaky Gut) Plays a Role in the Inflammatory Pathophysiology of Depression." Neuro Endocrinology Letters 29, no. 1 (2008): 117-124.
Pavlov, Valentin A., and Kevin J. Tracey. "The Vagus Nerve and the Inflammatory Reflex: Linking Immunity and Metabolism." Nature Reviews Endocrinology 8, no. 12 (2012): 743-754.
Zhou, Lei, and Jane A. Foster. "Gut Microbiota: Influences on Brain and Behavior." Frontiers in Cellular Neuroscience9 (2015): 235.
Cecchini, Maria, and Esther M. Sternberg. "Sympathetic Nervous System Interactions with the Immune System in Inflammation and Autoimmune Disease." Brain, Behavior, and Immunity 37 (2014): 1-10.
Martínez, Ignacio, Christine E. Muller, and Jens Walter. "Healthy Human Gut Microbiota: Factors That Influence Its Composition and Their Consequences." BioMed Research International 2013 (2013): 1-13.
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by Dr. Monisha Bhanote
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